a. 1. Affected with canker; as, a cankered mouth. [ 1913 Webster ]

2. Affected mentally or morally as with canker; sore, envenomed; malignant; fretful; ill-natured. “A cankered grandam's will.” Shak. [ 1913 Webster ]

adv. Fretfully; spitefully. [ 1913 Webster ]